How to Not Die | David Sinclair | Knowledge Project 136 The Knowledge Projectčas přidán Před dnemzhlédnutí 151K 3,6K 96K StaženíKomentáře: 334 The Knowledge ProjectPřed 3 měsíciTimestamps: 00:00 - Intro 01:24 - What is aging? 02:52 - What happens in our body during aging? 06:10 - How fasting decreases aging 15:00 - On eating three meals a day 18:39 - The best things to eat to reduce aging 23:05 - Organic v non-organic foods 27:04 - Should we only eat food that's "in season?" 29:46 - On sugar 31:42 - How to test your biological age 33:22 - Using exercise effectively 36:18 - Sleep and aging 40:36 - The benefits of saunas and hot tubs 45:04 - The relationship between stress and aging 47:55 - How positive attitude impacts lifespan 48:34 - NMN, Athletic Greens, and resveratrol 52:57 - Why David quit dairy (and did it matter?) 58:00 - When should you start slowing your aging process? 01:01:05 - On puberty and aging 01:02:53 - Are biological problems becoming engineering problems? 01:08:54 - Using drugs to reverse aging 01:11:24 - On lyme disease 01:17:06 - On hip-replacement and increased death rates 01:21:36 - How to think about aging before it's too late 01:23:30 - What's the ultimate age we can live? 01:28:30 - Second-order effects of living longerJoan FisherPřed 2 měsícipD- GranterPřed 2 měsíciim holding all the keys to the evolution of society but not without yourself, hyberman, clive de carle, a list of others to step in the complex we need a good space studio aswel and its not that complicated adam savage has team just ready and waiting but theyll be busy enough with thier own version as it will be compteting against ours but well all be chilling in a space hotel one way or another were racing against having to fend off the mad max era when we should be running rings around utopiaNidiya GasparPřed 2 měsíciThank you 🙏🏻5 mins leftPřed 2 měsícias much of a scientist he is, he does show a lot of human sides in him. No fancy terminology, his messages are easy to understand yet with precision and conciseJagan .VamanPřed 2 měsíciDavid is a humble and compassionate scientist...though his achievements are great. His personal traumatic experience with losing his mother shows his human side. I read his book lifespan...brilliant! I am on omad, metformin 2G, niacin, quercetin, veg diet no diary no alcohol 40 min walks....I feel great at 61!. I have never felt better even at 30! More power to you Dr David Sinclair! Medicine plus technology is going to revolutionize how we live longer and healthier....Zbigniew BrzezinskiPřed 2 měsíciIs 2 gr Metformin not too much?shekataganiPřed 2 měsíciYou don't need to go as long as 3 days for Major Health benefits, Eating one meal a day and eating whole foods, cutting Carbs and Sugar, limit Alcohol. Do this with a little exercise and you will be a very fit person. I am 67 and I've taken on this way of living and I'm more healthy now than I was 20 years ago.Ted PPřed 2 dnyNot many people have the will power to follow this plan but it worksElizabeth KPřed 20 dny@Marjake red grapes are loaded with fructose. One of the worse fruits to consume.Elizabeth KPřed 22 dnyI'm 75, and feel and look, feel, and 20 years younger. Keep it up. 👍Sema AralPřed měsícem@shekatagani Thank you, I know but liked to know your secret to staying young, my question is your way to staying young. I otherwise follow our Scientist Protocol🌸 Have a lovely Sunday 🙏🌺Interpret ThisPřed 9 dnyGreat interview. It's interesting to talk about this subject, specifically aging and what the average human lifespan is, and what it could become if we only took better care of ourselves. The majority of the population, it seems, doesn't understand the impact of quality sleep, good diet, regular exercise (even 15-20 minutes a day), and sun protection on general health (and looks). I have a couple of friends who wouldn't even try to reduce their coffee intake, even though they've been experiencing major sleep disturbances for years now.Sophie Před 2 měsíciFantastic interview. I've watched many interviews with David Sinclair and this was the best by a long mile. You've definitely got a new subscriber here!හරි මග උදෙසාPřed 2 měsíciProfessor David has been educating us in order to live happily and healthier with a purpose to serve mankind. Excellent episode. Thanks a lot.Dr.Jayanth Pathirana AttorneyMyrslokstokPřed měsícemI sean a dussin of Davids interviews videos but his comfortable her this is a good one.Adil DuredoranPřed 2 měsíciWhat a great interview and the host has been extremely patient and asked great questions 👍. SubscribedMD BonifasioPřed 2 dnyThis was such a good podcast! Thank you for keeping it simple and letting the messenger spread the message without an exaggerated amount of ads constantly interrupting! Thank you!MJ GrantPřed 2 měsícigreat interview. thank you for the time stamps, they are super valuable when wanting to zero in on topics. i wish all interviewers did this.Nancy LucasPřed měsícemThank you. Great interview, and definitely informative. Doing most of these things, except drugs and monitoring for several decades. You talked about research/clinical studies I definitely am going to go looking up to read. @Shane and @ Dr Sinclair so sorry for all your troubles with Lyme disease and an unresponsive healthcare system.Henriett HadlerPřed 2 měsíciWow! I have been following David Sinclair for a while now, but this interview was the best. Thank you Shane (? - sorry if misspelled your name) for your questions. You two are a match made in heaven and please keep conversing and do more Q&As in the future. You asked questions that make us think in a broader sense what it means to have a longer life. The impacts on society, environments, etc. I hope you two had a good time- there seemed to be a real mutual respect and synergy that came through the screen. I keep following David Sinclair's works; share this interview with my teens so we can converse more about longevity. As a mum it's my responsibility to raise them well and good foundations for health is part of that. And I subscribe to this channel without even knowing what to expect- but oh boy I enjoyed this session so much, you sold me the rest of stuff you do. Thanks for both of you your time and work and thanks for your teams behind the scenes.Grant BurrisPřed 2 měsíciDavid, I follow all your talks. I have for about two years. I liked this one better than the ones with the guy who has the silly hat. This was well done. Just my opinion. Thanks for all the information you have been supplying. It very useful.Levon DarrattPřed 12 dnyIt's just a hat. Nothing silly about it. And he's very smart.Judith HatchPřed 2 měsíciWell his podcast "silly hat guy" who is lovely but interrupts David often and David you actually do very well explaining what could be dense material , data well.MyrslokstokPřed 2 měsíciThe sergion!TRANSFORMATION CENTRALPřed 2 měsíciI too am super-impressed with both the interview and with David. I am motivated by hearing him say that his biological age is 20!!! (at 52). I'm sold on giving some of these "pathways" a go. Particularly NMN, RESVERATROL, and Metformin.... Really appreciated this interview. Thank youGrant BurrisPřed 2 měsíciDavid, I made my original comment when the talk was half over. Now that I have heard the entire episode, I want to stress again, how valuable this talk was. This was miles ahead of all the others. Thank you.Myrna alexanderPřed 2 měsíciI so enjoy your podcasts! Follow in my life and encourage my clients to do. I am psychotherapist and nutritionist.Linda MarshPřed měsícemDr. Sinclair's Mom and Grandma would be very proud of him. Helpful and kind man.Robert KuiperPřed 2 měsíciThank you David for the open heart and inspiration!Aaliyah LeePřed 2 měsíciLife expectancy is the average length of life of a group of individuals. The way to increase this is to get more individuals to live longer than the current average than die sooner. One way to do this is to persuade the members of the group to eat a healthy diet in moderation and to get regular exercise. I have been watching Dr. Sinclair's interview and bought his book “Why We Age and Why We Don’t Have To” very eye-opening and educative. In there, there's no point increasing lifespan without health span. The goal should be to live longer while staying young and healthy. Sinclair believes that in the foreseeable future, it's possible for humans to live beyond 120 or even 150, without the frailty, diseases and disability we now associate with old age. I hate aging and the illnesses it brings over time. NMN Vitruvin Health is the most cost-effective brand for me.Mary TPřed 26 dny🔥🔥👏👏👏 … finally someone who really cares about the TRUTH of eating , fasting and why …….. I admire YOU and your courage to speak FACTS and educate others !!!! 🙏🏻🙏🏻🙏🏻SueAnn CrawfordPřed měsícemWhen I contracted Lyme disease I also had paralysis in my face as well as a bullseye rash, and I was treated like I was crazy. The initial testing came out negative so they told me there’s no way I had Lyme disease. When I finally got diagnosed after taking it into my own hands It had been 12 years. As a result I still have remaining paralysis in my face after being on antibiotics for five years in order to get it under control. It’s medieval the way they handle Lyme disease.Bhvn RajuPřed měsícemExcellent conversation, Amazing scientific INSIGHT, Thanks to THINKER cum WELL WISHER 🙏🙏g bPřed 2 měsíciThis interview was the best a watchbon the last time. It's blow my mind !! So much precius information. Absolutly excellent .MyrslokstokPřed měsícem⭐️⭐️⭐️⭐️ This is a great interview with David, with additional timestaps, thanks! If it is possible maybe you can cut in some wiki-pages here and there for us non english speakers. Ex Limes decise we even got TBE in Sweden 🇸🇪 its basicly the only dangerus thing here, except for a snake if you are unlucky. If I could se the wiki page I wouldn't have to wiki it.Anne williamsPřed 2 měsíciFor the last few months, I've been taking one tablet each day of NMN-Vitruvin Health supplement. I'm astounded to discover that my metabolism now functions as well as it did when I was a younger. Other outcomes aren't nearly as visible yet, but I saw a significant boost in energy and concentration. I'm going to order another few rounds from their website. It took around just 3-4 days to see a difference.orion9kPřed 2 měsíciI've been taking nmn for 5 days now, 200 and 300 mg, but I'm not feeling much from it. I also started taking b3 Nicotinic acid with flush effects and this seems to work pretty well, the flush effects feels like when you go from sauna to ice water and back into sauna, it's so nice a feeling but not everyone likes this feeling.amber skiesPřed 2 měsíciOh, that's so good to hear from a Vitruvin user like you.. keep it up! 😇KenPřed měsícemThe questions were great and I truly enjoyed the talk. Thank you! SubscribedEdgbarraPřed měsícemI didn't know he was eating mostly a plant based diet, that's quite interesting to consider. I'm definitely gonna do it tooBronson StonePřed dnemGreat interview. Can David tell us how much protein should be consumed each day. I'm somewhat perplexed because all I can find is recommendations to eat 1.2 to 2 grams per kg of body weight, I weigh 110kg and cannot eat 130g of protein, I struggle with 60g.Milena DelTortoPřed měsícemThank you so much. Great talk!Suzanna DwyerPřed 2 měsíciIt fascinates me that you and many others talking about longevity are young, 40's 50's t most. I am 80 and often wonder what you will be saying in 10 or 20 years. True I was fortunate to receive the longevity genes, I have brothers who are 84 and 85 and quite healthy too, but there must be other factors at work that you are not detecting.a------------Před měsícemHe said genes is 20% of it. Did you listen to the whole podcast? The other 80% he was talking about were all the other factors that affect and slow aging. Everything from what you eat, when you eat, exercise, sleep, supplements, stress and then some more not mentioned here.EdgbarraPřed měsícemThe thing is, what he promotes is not mainly based on his experience, it's based on scientific research. After that he started to implement this on himself and has some anecdotal evidence, but the science is were our focus should be in my opinion.lia laiePřed 2 měsíciAnd we have octogenarians in other cultures who dont have the "ease" of western lifestyles or latest medical "treatments".dihuscientistdjPřed 2 měsíciSimple wow! Absolutely phenomenal M. BaderPřed měsícemThis and many other talks by Dr Sinclair are so interesting and inspiring. If you're seeing this dr sinclair can you tell me if you are basically consuming all your required calories intake in one go each day? If you are regularly fasting and only eat once, how do you eat possibly 1500 to 2000 or more calories on one meal or are you consuming a low calorie diet? Do you ever let yourself go when on holiday and eat local snacks ? Also curious to know if everyone eventually ends up with some insulin resistance over time?FRITS FLAP EARSPřed 2 měsíciI'm happy Sinclair admits his sleep habits are not optimal, its the same as me. Many nights i don't even sleep, i know it's bad, but this is reality. I worry too much and need to change it. But i never wear jackets, even not when its below minus 10°C and i am much younger looking than my brother and cousins who are bald grey already for yearsJavad HashtroudianPřed měsícemAt 75 I have been practicing intermittent fasting for about 20 years. I exercise most days. Recently I started taking nmn and berberine as well as other supliments . I weigh less than I did 50 years sgoJudith HatchPřed 2 měsíciactually I'm doing well with the one meal a day , just on my 4th day, but going well. Drink my coffee in morning, followed by water, hot non caffeine tea and water in afternoon. Getting off my butt every hour walk around trying to get 4000 steps a day and more on days off. Whole non processed plants, fruit, egg and fish, beans. 65yo will see how it goes. but can tell fluid retention down, less joint pain already. This is for long haul. As I age in years want quality of life while I'm here. Dr. Sinclair has tapped something in me to be motivated., thank you!YeeMing B ChanPřed měsícemThank you so much, grateful to both of you! i 'd like to translate or rephrase the main ponts here and will write your channel as my source, do u mind pls, Shane. i think this is so interesting and impressive , many peple can benefit from watching your interview! so please!Kim WolfePřed 2 měsíciThank you for sharing your life! Notes taken…Vassiliki StathopoulouPřed 2 měsíciAmazing scientist!Sue BostockPřed 2 měsíciHI- thanks so much for this information. Does this mean that (plant based) protein shakes don't help longevity, even if we fast for 14 hours?Richard BelusaPřed 26 dnyMy doctor prescribed medicine because he said I should watch my cholesterol that I should keep it very very low. I never took his medication but I changed my diet change my diet I went back to him 6 months later and he said wow did it ever work so good I've never seen the drug works so well and I told them I didn't take the medicine I changed my diet and he changed the subject. He never asked and wasn't curious what I did.Donna OliverPřed 20 dnyI have a rookie question: If one started these strategies and then couldn't continue for any reason, would there be a 'rebound' effect (e.g. Flowers for Algernon) or would the person just continue from where they are? Sorry if this is a ridiculous questions, I'm not a biologist, but really interested in this work.B RPřed 2 měsíciI love this guy...he literally is a gene...iousMatt jPřed 3 měsíciExcellent roundoff of some wonderful techniquesDEB WESTPřed 2 měsíciI have always slept few hours even though I never do caffeine. I began taking NMN in the morning and immediately felt a jolt like caffeine. Now I can not sleep longer than 4 hours. I want more sleep.aoifewestPřed 2 měsíciAshwagandha might help uDorin BivolaruPřed měsícemBrilliant. Very greatful. ThanksGina BaronPřed měsícemMy father's spiritual teacher in Indonesia called Bantong became 160 yrsOlaf -Před měsícemThe real key to human happiness isnt living longer. Its having the ability to turn it off without pain when you want to.OttoPřed 23 dnyYou are right but it is also about staying healthy while aging and that's what Sinclair is talking about.Sebastian NiemannPřed 2 měsícigreat interview 🙏🖖❤️Richard BelusaPřed 26 dnyIt's actually easy to get the 3 days you have to build-up to it once you build-up to it you'll find not eating it's just somehow you realize you have so much more time because there's no cooking and dishes and stuff no time wasted at the table eating and in the 3rd day of the while I've had so much time it feels like a whole week went by. Mind you I live alone. I used to get really sick with nausea after missing one meal now I can go 3 days with no problem no side effects or anything. Just practice it you'll see how easy and you'll get there.FreeMoceanPřed 2 měsíciDavid is 5 months older than me. Will be interesting to see how we both age over the next 8 years. I’m full carnivore + coffee. I focus on about 20 min day of strength and mobility work. Randle cycle is my priority. I recommend Bart Kay for actual science on human nutrition. Time will tell.Anna AbrantePřed 16 dnyThanks for the laugh.EdgbarraPřed měsícemDr Sinclair is on the top of the field in longevity. I think his findings after so many years of research would be consider "actual science" 🤷🏻Creighton FreemanPřed 2 měsíciRegarding sleep, the Yogi Sadghuru says rest is essential, but distinguishes between rest and sleep. Most people do not know how to rest without sleeping though. I have noticed that when doing certain kinds of breath work, I need less sleep.一肩十里怕不怕Před měsícemHi Dr Sinclair, I have read your journal on 2013 regarding mitochondrial decreasing with ageing. But how about telomere and telomerase participation?LaaneyChoonzPřed 2 měsíciDavid Sinclair should write a Cookbook! Foods to live longer!RohanPřed 2 měsíciHe doesn't eat! He fasts!Jen HolmesPřed 2 měsíciMaybe he can’t cook?Nancy LucasPřed měsícemThank you for the information about turning on mTOR, sirtuitins, and AMPK by eating vegetable-based protein.ilya b.Před 2 měsícicurrently i stopped intermittent fasting because there is a drawback, you have difficulties to keep lean muscles. As i try to be an advanced athlete, I feel better with proteins and enough nutrients. The last thing you want is to fall and break a hip when you are old (it is like a death sentence) so i need to maintain strong muscles and reduce muscle wasting due to aging. i still adhere to midetterenian diet of course.OmanPřed 2 měsíciThis has really changed my opinion on the carnivore diet. Like steroids and drugs they make you feel good but it could have long term negatives.Clement ViningPřed měsícemBut there is no evidence that long term has a negative effect. In fact there seems to be evidence it is beneficial long term as long as you get all the necessary nutrients.Kim ShilesPřed 2 měsíciReally great point!April MichaelPřed 2 měsíciOne of ny faves Mr Sinclair. You're one of very few docs I listen to whenever you upload new episodes. Cheese & wine ohhh my food. Noooo 🙆♀️🙆♀️😥Paula Ballet DancerPřed 2 měsíci@Joseph O that is beyond my reply above. I only stated fact not conjecture. Thank you.Joseph OPřed 2 měsíci@Paula Ballet Dancer *The fact is he knows more and has performed or supervised more experiments published in peer review journals than the majority of "MD's".*Paula Ballet DancerPřed 2 měsíciDavid is a PhD scientist but not an MDJatinder SinghPřed 2 měsíciWhat are the tests available to see your health and age? You may live really long, time is changing. Thanks.Bri TerryPřed 24 dnyNo one ever asks where he gets his Resveratrol and NMN from... really all I wanna know at this point!Wisconsin FarmerPřed 2 měsíciGreen tea, I have discovered is a good partner to fasting. Energizing and helps resist hunger.falcon127Před měsícemTHANKS, GUYS GREAT VLOG!AgapanthahPřed 2 měsíciGreat job...subscribedGina KhaziranPřed 2 měsíciThank you for your time and advise 🙏, which kind of NMN, is good?01maggiePřed 2 měsíciMy 98 year old Mom sleeps 12 hours every night. She was always napping when I was a little girl. She said even as a child she would sleep until noon on weekends. Friends would come to play and her mother said .. Florence is still sleeping... Maybe she has a lot of melatonin in her system??? By the way she will be 99 this October!! She had covid a few months ago and did well!! Actually better than me... I found the NMN and Transreservatol saved me from long covid. Wish I took it during the acute phase .. Also chaga mushroom..game changer...stops cytokine storm which happens with Covid!! Chaga also kills cancer!!Wisconsin FarmerPřed 2 měsíci@Dr. Delaney on Dreams The great religious leap backward.Dr. Delaney on DreamsPřed 2 měsíci@just no Lucky, and smart YOU! Glad not everyone has gone back to the prudish days re-instated by Regan in the early 80s.just noPřed 2 měsícime tooo haha i love to sleep.. and just lying down, resting and alone with my thoughts. my mind entertains me than my phone. its funny and beautiful and by this habit, i get know and trust myself more. it even has a function of making me orgasm (i know this sounds crazy, and i shouldnt mention this) by just lying down and letting my mind wander and the body do it thing lol.. music can make my cells tingle as well... i dk if this contributes to longevity but i just love sleeping and napping and finding sweet spots in my breathing patterns. its so relaxing. i eat once a day as well and very little because i consume little energyAlex BerukoffPřed 2 měsíciOUT OF 22 THIRD PARTY TESTING FOR NMN ONLY THREE HAD ALMOST THE AMOUT CLAIMED ON THE BOTTLE,, THREE HAD NONE AT ALL AND THE REST HAD 1%Nixon ChanPřed měsíceml do ~ 72hours water fast a week, and when eat, l do alot, over ~3-4hours l feel totally fine, l exercise daily as well, with heart beat about 70-80% max for ~2 mins a 1hour session which includes yoga,. is this healthy habit? opinions?Louis Peter JettooPřed 11 dnyEnjoy life, be happy, self control, discipline, Enjoy working, don't put things off if you can do it today, play sports, be active, dancing, there's time for everything, but don't be lazy. Swim, fish, the Mind and body must be busy and rest when tired, but always looking forward, a bit exited for the next day, there's always something to do. Don't get into a habit of putting things off for later. Love and enjoy everything you do, learn to enjoy the things you don't like to do, I mean don't do things like breaking the law. Love and forgive is a priority. Follow your subconscious or dreams and never give up. Thank you 😊 💓Kelly SerafinaPřed měsícemOh good lord. No wonder I'm sleeping less nowadays. I am taking NMN/Resveratrol at night right after dinner, which I didn't realize was kick starting the energy cycle in my body. My bad. I was trying to keep the OMAD clean by not eating in the morning, the yogurt that I put the NMN & resveratrol powder into, but I guess I'll have to start taking it in the morning.Joseph WhittlePřed 2 měsíciDavid, please tell us about linoleic acid and how to lower our exposure.Levon DarrattPřed 12 dnyThe laughing muscles get a workout by watching Schitt's Creek . That's anti-aging right there.720 ZonePřed měsícemInteresting fact: David is 94 years old.Debra, RNPřed 2 dny🤣😂🤣😂🤣Richard MiddletonPřed 2 měsíciInteresting about eating less protein increases life yet being strong with a good amount of lean muscle mass is also linked to increase life expectancy. I'm confused now! Is it simply animal protein that should be minimised?EdgbarraPřed měsícemFor what I got it seems like it was protein in general. But I have the feeling it's because we're kinda obsessed with high protein. Our ads promote it a lot. I think Sinclair recommend 0.5 gr of protein per kilo of body weight (I'm not sure tho). With that you can build muscle, maybe not for weight lifting competition but certainly for lean strong bodyWendy MPřed 2 měsícifollowingquestionmarkPřed 2 měsíciExactly my thought. Would be better if he elaborates. Missed opportunity.Gary JohnsonPřed měsícemWhere can you get these 3 supplements as in which firms would you recommend?Esther JaediPřed 2 měsíciIv now listed to several podcasts like this to living your best health with longevity in mind. However, all you scientist drs do mention in your videos that a good protein diet, resistance exercising, good sleep, meditate, de stressing and positive attitudes contribute to this. What I’m still confused about is that one Dr says that the carnivore diets supersede the plant protein diets. Tho Dr Sinclair discourages carnivore as not good at all for longevity. Why is this so controversial. Thank you. Great interviewEdgbarraPřed měsícemSr Sinclair is on the top of the field of longevity. I would definitely listen to him instead almost anyone else. About the carnivore diet, for what I heard from him and Dr Patrick, it seems like there are not enough scientific evidence of long term effects. The data is mostly anecdotal so it's not super reliable. Instead they encourage to eat based on the science available. So mostly whole plants, avoiding complex sugarsCharles PetersPřed 2 měsíciIt does seems like Drs who like the carnivore or "keto" diets are taking a somewhat different tack from Drs like Sinclair who is saying plant based is better. I think both have in common the idea of limiting carbohydrates to enhance fat burning and reduce insulin spikes. When you fast for 16 hrs like Sinclair and others recommend your body may be achieving ketogenisis for the last couple of hours of your fast. And maybe the benefits of that are enough to get most of the benefits without being keto for 24/7 on the carnivore diets. I think as we learn more about the long term effects of these different diets the best practices will be clearer. As Sinclair states there is no best diet for eveyone. It depends on your age, sex, genes, activity level, etc.Tim MortimerPřed dnemA new world of possible right in front of our eyesMohib QuadriPřed 3 měsíciGreat One ⭐Nikki ShevilloPřed 2 měsíciDo you think NMN stimulates growth of cancer cells if ur prone to breast cancer since it promotes dna, cells, etc? Thx!!JamesPřed 2 měsícithis dude does not go very long without mentioning he is working on or discovered whatever he is saying is importantpopothebrightPřed 2 měsíciHe looks a lot older than the last time I saw him.RustyBoltsPřed 2 měsíciFor about the past 25 years or so, I have been comparing myself to 'Infinity' only to find my life span infuriatingly smaller than my human imagination can reveal. Something has to be wrong. Immortal jelly fish and others have been immortal for millions of years. What is wrong with us? We are supposedly so evolutionary advanced. Something must be seriously wrong with the model and the theory. Any ideas please?